Grants awarded in 2017

Prof. Hans H. Jung, Department of Neurology, University Hospital Zürich
Clinical and genetic characterization, natural history and biomarkers in Swiss patients with inherited peripheral neuropathies

Dr. Simone Schmidt, Neuropediatric Department, University Children’s Hospital Basel
Observational follow-up of Duchenne muscular dystrophy patients from the DMD02 trial

Prof. Susan Treves, Departments of Anesthesia and Biomedicine, University of Basel
Dysregulation of excitation contraction coupling and ophthalmoplegia in a   mouse model knocked in for compound heterozygous ryanodine receptor (RYR1) mutations

 

Grants awarded in 2016

Dr. Ruben Herrendorff, Pharmazentrum, University of Basel
Anti-MAG neuropathy mouse model and in vivo validation of PN-1007 (continuation 2nd year)

Dr. Paolo Ripellino, Neurocenter of Southern Switzerland, Ospedale Civico, Lugano
Autoantibodies related to HEV-induced neuralgic amyotrophy

 

Grants awarded in 2015

Dr. Ruben Herrendorff, Pharmazentrum, University of Basel
Anti-MAG neuropathy mouse model and in vivo validation of PN-1007

Dr. Bernhard Schneider, Brain & Mind Institute, EPFL, Lausanne and Dr. Roman Chrast, Department of Neuroscience, Karolinska, Stockholm
An integrative approach to characterize (and potentially prevent) alterations in neurons, glia and muscle cells induced by CMT2A, an axonal form of neuropathy

Dr. Jérôme N. Feige, Nestlé Institute of Health Sciences, EPFL, Lausanne
Cholesterol metabolism in Schwann cells during neuromuscular aging

 

Grants awarded in 2014

Prof. Markus A. Rüegg, Biozentrum, University of Basel
Repair of laminin-deficient muscular dystrophy with synthetic linker proteins

Prof. Dr. med. Michael Sinnreich, Neuromuskuläres Zentrum, Neurologie,
Universitätsspital Basel
Understanding the pathomechanism leading to Myotonic Dystrophy type 1: Role of mTORC1 imbalance and autophagy impairment in DM1-associated alterations of skeletal muscle

Prof. Dr. med. Hans Jung, Department of Neurology, University Hospital, Zurich
Influence of physical activity on mitochondrial function in mitochondrial myopathies, Huntington disease and normal aging

 

Grants awarded in 2013

Prof. Dr. Christoph Handschin, Biozentrum,  University of Basel,
Global analysis of RNA processing in muscle cell-motor neuron co-cultures of spinal muscular atrophy (SMA) patients

Dr. Christian Neuwirth and Prof. Markus Weber, Muskelzentrum ALS clinic,  Kantonsspital St.Gallen
A novel neurophysiological measurement (MUNIX) in neuromuscular disorders, test-retest reliability and longitudinal follow-up measurements in amyotrophic lateral sclerosis patients in a multi-centre study

Dr. Susan Treves, Perioperative Patient Safety Group, Departement Biomedizin, University Hospital Basel
Myopathies caused by recessive ryanodine receptor (RYR1) mutations: is there a causative link between abnormal microRNA expression and reduced ryanodine receptor protein expression

 

Grants awarded in 2012

Prof. Dr. Michael Sinnreich and Ruben Herrendorff, Msc, Departments of Biomedicine and Neurology, Neuromuscular Research, Basel
Identification of novel lead compounds for the treatment of Myotonic Dystrophy type 1

Dr. Stefania Puttini, Laboratory of molecular Biotechnology, University of Lausanne
miRNAs as serum biomarkers for diagnosis of degenerative or inflammatory myopathies

Dr. Lionel Tintignac, Biozentrum University of Basel
Inhibition of myocellular breakdown for the prevention of disease-associated muscle weakness

 

Grants awarded in 2011

Prof. Dr. med. S. Frank, Department of Neuropathology, Institute of Pathology, University of Basel
Exploring the role of the mitochondrial fission protein DRP1 in motoneuron function and survival

PD Dr. med. D. Fischer, Departments of Pediatrics and Neurology, University Hospital Basel
A pilot study to evaluate the effect of L-arginine and metformin in Duchenne’s muscular dystrophy

 

Grants awarded in 2010

Prof. Dr. Michael Sinnreich, Department of Biomedicine, Pharmazentrum, Neuromuscular Research, Basel
Novel sequence capture method for molecular diagnostics of neuromuscular diseases

Prof. Dr. Roman Chrast, Department of Medical Genetics, Lausanne
Analysis of the role of Sh3tc2, protein affected in Charcot-Marie-Tooth 4C disease, in the regulation of Schwann cell myelination

 

Grants awarded in 2009

PD Dr. S. Treves, Departments of Anesthesia + Biomedicine, Basel University Hospital, Basel
The effect of mutations in the ryanodine receptor calcium channel and its link to the neuromuscular disorders Central Core disease, Multiminicore disease and Malignant Hyperthermia

Prof. H.R. Brenner, Department of Biomedicine, Pharmazentrum, Basel
Neuronal Agrin and acetylcholine receptor dynamics at the neuromuscular junction in vivo

 

Grants awarded in 2008

Prof. Markus A. Rüegg, Pharmacology/Neurobiology, Biozentrum, Basel
Does the angiotensin II type 1 receptor antagonist losartan ameliorate disease progression in MDC1A?

PD. Dr. Susanne Renaud, Neurology, University Hospital, Basel
Molecular biological characterization of skin biopsies of patients suffering from inflammatory and dysimmune polyneuropathies